학술논문
Repression of GSK3 restores NK cell cytotoxicity in AML patients
Document Type
article
Author
Source
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Natural killer cells of acute myeloid leukaemia patients lack cytotoxic activity. Here the authors show that these cells have elevated GSK3β, and that its inhibition prolongs survival of mice transplanted with human AML and stimulates NK cytotoxicity via increased adhesion of NK cells to their targets.