학술논문
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria
Document Type
article
Author
Andre Mu; William P. Klare; Sarah L. Baines; C. N. Ignatius Pang; Romain Guérillot; Nichaela Harbison-Price; Nadia Keller; Jonathan Wilksch; Nguyen Thi Khanh Nhu; Minh-Duy Phan; Bernhard Keller; Brunda Nijagal; Dedreia Tull; Saravanan Dayalan; Hwa Huat Charlie Chua; Dominik Skoneczny; Jason Koval; Abderrahman Hachani; Anup D. Shah; Nitika Neha; Snehal Jadhav; Sally R. Partridge; Amanda J. Cork; Kate Peters; Olivia Bertolla; Stephan Brouwer; Steven J. Hancock; Laura Álvarez-Fraga; David M. P. De Oliveira; Brian Forde; Ashleigh Dale; Warasinee Mujchariyakul; Calum J. Walsh; Ian Monk; Anna Fitzgerald; Mabel Lum; Carolina Correa-Ospina; Piklu Roy Chowdhury; Robert G. Parton; James De Voss; James Beckett; Francois Monty; Jessica McKinnon; Xiaomin Song; John R. Stephen; Marie Everest; Matt I. Bellgard; Matthew Tinning; Michael Leeming; Dianna Hocking; Leila Jebeli; Nancy Wang; Nouri Ben Zakour; Serhat A. Yasar; Stefano Vecchiarelli; Tonia Russell; Thiri Zaw; Tyrone Chen; Don Teng; Zena Kassir; Trevor Lithgow; Adam Jenney; Jason N. Cole; Victor Nizet; Tania C. Sorrell; Anton Y. Peleg; David L. Paterson; Scott A. Beatson; Jemma Wu; Mark P. Molloy; Anna E. Syme; Robert J. A. Goode; Adam A. Hunter; Grahame Bowland; Nicholas P. West; Marc R. Wilkins; Steven P. Djordjevic; Mark R. Davies; Torsten Seemann; Benjamin P. Howden; Dana Pascovici; Sonika Tyagi; Ralf B. Schittenhelm; David P. De Souza; Malcolm J. McConville; Jonathan R. Iredell; Stuart J. Cordwell; Richard A. Strugnell; Timothy P. Stinear; Mark A. Schembri; Mark J. Walker
Source
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Severe sepsis has a high mortality rate. Here, the authors provide genomic, transcriptomic, proteomic and metabolomic data across four sepsis-causing pathogens and identify a signature of global increase in fatty acid and lipid biosynthesis as well as cholesterol acquisition.