학술논문
Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with Subtype and Stage Inference
Document Type
article
Author
Alexandra L Young; Razvan V Marinescu; Neil P Oxtoby; Martina Bocchetta; Keir Yong; Nicholas C Firth; David M Cash; David L Thomas; Katrina M Dick; Jorge Cardoso; John van Swieten; Barbara Borroni; Daniela Galimberti; Mario Masellis; Maria Carmela Tartaglia; James B Rowe; Caroline Graff; Fabrizio Tagliavini; Giovanni B Frisoni; Robert Laforce; Elizabeth Finger; Alexandre de Mendonça; Sandro Sorbi; Jason D Warren; Sebastian Crutch; Nick C Fox; Sebastien Ourselin; Jonathan M Schott; Jonathan D Rohrer; Daniel C Alexander; The Genetic FTD Initiative (GENFI); The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Source
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Subject
Language
English
ISSN
2041-1723
32293844
32293844
Abstract
Progressive diseases tend to be heterogeneous in their underlying aetiology mechanism, disease manifestation, and disease time course. Here, Young and colleagues devise a computational method to account for both phenotypic heterogeneity and temporal heterogeneity, and demonstrate it using two neurodegenerative disease cohorts.