학술논문
Glucose promotes cell growth by suppressing branched-chain amino acid degradation
Document Type
article
Author
Source
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Hypertrophic cardiomyocytes switch their metabolism from fatty acid oxidation to glucose use, but the functional role of this change is unclear. Here the authors show that high intracellular glucose inhibits the degradation of branched-chain amino acids, which is required for the activation of pro-growth mTOR signaling.