학술논문

High-resolution anoscopy predictive modeling of anal canal cancer response after definitive chemoradiotherapy in COVID19 era
Document Type
article
Source
Translational Oncology, Vol 27, Iss , Pp 101590- (2023)
Subject
High-resolution anoscopy
HPV
Anal canal cancer
Radiotherapy
Response
Treatment failure
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Language
English
ISSN
1936-5233
Abstract
Purpose: To develop a predictive index model, integrating both clinical and high-resolution anoscopy (HRA) features to further personalize the decision making process in anal canal carcinoma in COVID19 era. Methods and materials: We assess HRA parameters after definitive chemoradiotherapy in patients with anal canal malignant lesions. Results: HRA features could be important to assess the effect of CRT and a risk stratification system should be introduced in clinical practice to better allocate therapeutic interventions. Conclusion: To our knowledge this is the first proposal for HRA findings in anal canal cancer after definitive CRT. We believe that a risk score can be useful to estimate the risk of treatment failure (in term of persistence disease and/or recurrence) and its clinical relevance should not to be underestimated.