학술논문
Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers
Document Type
article
Author
Tom Van Nyen; Mélanie Planque; Lilian van Wagensveld; Joao A. G. Duarte; Esther A. Zaal; Ali Talebi; Matteo Rossi; Pierre-René Körner; Lara Rizzotto; Stijn Moens; Wout De Wispelaere; Regina E. M. Baiden-Amissah; Gabe S. Sonke; Hugo M. Horlings; Guy Eelen; Emanuele Berardi; Johannes V. Swinnen; Celia R. Berkers; Peter Carmeliet; Diether Lambrechts; Ben Davidson; Reuven Agami; Sarah-Maria Fendt; Daniela Annibali; Frédéric Amant
Source
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Metabolic reprogramming is associated with cancer development and therapy resistance. Here, the authors show that downregulation of the serine biosynthesis enzyme PHGDH in a fraction of patients is associated with relapse in platinum-treated ovarian cancers and to NAD+ and PARP activity upregulation.