학술논문
The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
Document Type
article
Author
Daniel J. Ham; Anastasiya Börsch; Shuo Lin; Marco Thürkauf; Martin Weihrauch; Judith R. Reinhard; Julien Delezie; Fabienne Battilana; Xueyong Wang; Marco S. Kaiser; Maitea Guridi; Michael Sinnreich; Mark M. Rich; Nitish Mittal; Lionel A. Tintignac; Christoph Handschin; Mihaela Zavolan; Markus A. Rüegg
Source
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition preserves muscle mass and function and neuromuscular junction integrity, whereas muscle-specific activation is associated with sarcopenia.