학술논문
Macrophage migration inhibitory factor is overproduced through EGR1 in TET2 low resting monocytes
Document Type
article
Author
Elodie Pronier; Aygun Imanci; Dorothée Selimoglu-Buet; Bouchra Badaoui; Raphael Itzykson; Thierry Roger; Chloé Jego; Audrey Naimo; Maëla Francillette; Marie Breckler; Orianne Wagner-Ballon; Maria E. Figueroa; Marine Aglave; Daniel Gautheret; Françoise Porteu; Olivier A. Bernard; William Vainchenker; François Delhommeau; Eric Solary; Nathalie M. Droin
Source
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
To improve our understanding of the pathological role of TET2 mutations, Pronier, Imanci et al. use mice and human cells to show that TET2 downregulation promotes the production of macrophage migration inhibitory factor (MIF). In addition they show that whilst TET2 is recruited to the MIF promoter in healthy monocytes, decreased TET2 expression results in chronic overproduction of MIF - suggesting that MIF signaling could therefore constitute a potential therapeutic target for conditions associated with TET2 mutations.