학술논문
Collateral status, hyperglycemia, and functional outcome after acute ischemic stroke
Document Type
article
Author
Daniel F. Arteaga; Robin Ulep; Kevin K. Kumar; Andrew M. Southerland; Mark R. Conaway; James Faber; Max Wintermark; David Joyner; Vera Sharashidze; Karen Hirsch; Dan-Victor Giurgiutiu; Yousef Hannawi; Yasmin Aziz; Lori Shutter; Anita Visweswaran; Alana Williams; Kori Williams; Sonya Gunter; Heather M. Haughey; Askiel Bruno; Karen C. Johnston; Vishal N. Patel; SHINE Trial Investigators
Source
BMC Neurology, Vol 22, Iss 1, Pp 1-5 (2022)
Subject
Language
English
ISSN
1471-2377
Abstract
Abstract Background Mixed data exist regarding the association between hyperglycemia and functional outcome after acute ischemic stroke when accounting for the impact of leptomeningeal collateral flow. We sought to determine whether collateral status modifies the association between treatment group and functional outcome in a subset of patients with large vessel occlusion enrolled in the Stroke Hyperglycemia Insulin Network Effort (SHINE) trial. Methods In this post-hoc analysis, we analyzed patients enrolled into the SHINE trial with anterior circulation large vessel occlusion who underwent imaging with CT angiography prior to glucose control treatment group assignment. The primary analysis assessed the degree to which collateral status modified the effect between treatment group and functional outcome as defined by the 90-day modified Rankin Scale score. Logistic regression was used to model the data, with adjustments made for thrombectomy status, age, post-perfusion thrombolysis in cerebral infarction (TICI) score, tissue plasminogen activator (tPA) use, and baseline National Institutes of Health Stroke Scale (NIHSS) score. Five SHINE trial centers contributed data for this analysis. Statistical significance was defined as a p-value