학술논문
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Document Type
article
Author
John R B Perry; Benjamin F Voight; Loïc Yengo; Najaf Amin; Josée Dupuis; Martha Ganser; Harald Grallert; Pau Navarro; Man Li; Lu Qi; Valgerdur Steinthorsdottir; Robert A Scott; Peter Almgren; Dan E Arking; Yurii Aulchenko; Beverley Balkau; Rafn Benediktsson; Richard N Bergman; Eric Boerwinkle; Lori Bonnycastle; Noël P Burtt; Harry Campbell; Guillaume Charpentier; Francis S Collins; Christian Gieger; Todd Green; Samy Hadjadj; Andrew T Hattersley; Christian Herder; Albert Hofman; Andrew D Johnson; Anna Kottgen; Peter Kraft; Yann Labrune; Claudia Langenberg; Alisa K Manning; Karen L Mohlke; Andrew P Morris; Ben Oostra; James Pankow; Ann-Kristin Petersen; Peter P Pramstaller; Inga Prokopenko; Wolfgang Rathmann; William Rayner; Michael Roden; Igor Rudan; Denis Rybin; Laura J Scott; Gunnar Sigurdsson; Rob Sladek; Gudmar Thorleifsson; Unnur Thorsteinsdottir; Jaakko Tuomilehto; Andre G Uitterlinden; Sidonie Vivequin; Michael N Weedon; Alan F Wright; MAGIC; DIAGRAM Consortium; GIANT Consortium; Frank B Hu; Thomas Illig; Linda Kao; James B Meigs; James F Wilson; Kari Stefansson; Cornelia van Duijn; David Altschuler; Andrew D Morris; Michael Boehnke; Mark I McCarthy; Philippe Froguel; Colin N A Palmer; Nicholas J Wareham; Leif Groop; Timothy M Frayling; Stéphane Cauchi
Source
PLoS Genetics, Vol 8, Iss 5, p e1002741 (2012)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
Common diseases such as type 2 diabetes are phenotypically heterogeneous. Obesity is a major risk factor for type 2 diabetes, but patients vary appreciably in body mass index. We hypothesized that the genetic predisposition to the disease may be different in lean (BMI