학술논문

Mechanoautophagy: Synergies Between Autophagy and Cell Mechanotransduction at Adhesive Complexes
Document Type
article
Source
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Subject
mechanoautophagy
Extracellular Matrix
focal adhesion
cadherin mediated adhesion
Autophagy
Biology (General)
QH301-705.5
Language
English
ISSN
2296-634X
Abstract
Cells are exposed and respond to various mechanical forces and physical cues stemming from their environment. This interaction has been seen to differentially regulate various cellular processes for maintenance of homeostasis, of which autophagy represents one of the major players. In addition, autophagy has been suggested to regulate mechanical functions of the cells including their interaction with the environment. In this minireview, we summarize the state of the art of the fascinating interplay between autophagy and the mechanotransduction machinery associated with cell adhesions, that we name ¨Mechanoautophagy¨