학술논문
HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders
Document Type
article
Author
Sigrid Le Clerc; Laura Lombardi; Bernhard T. Baune; Azmeraw T. Amare; Klaus Oliver Schubert; Liping Hou; Scott R. Clark; Sergi Papiol; Micah Cearns; Urs Heilbronner; Franziska Degenhardt; Fasil Tekola-Ayele; Yi-Hsiang Hsu; Tatyana Shekhtman; Mazda Adli; Nirmala Akula; Kazufumi Akiyama; Raffaella Ardau; Bárbara Arias; Jean-Michel Aubry; Lena Backlund; Abesh Kumar Bhattacharjee; Frank Bellivier; Antonio Benabarre; Susanne Bengesser; Joanna M. Biernacka; Armin Birner; Clara Brichant-Petitjean; Pablo Cervantes; Hsi-Chung Chen; Caterina Chillotti; Sven Cichon; Cristiana Cruceanu; Piotr M. Czerski; Nina Dalkner; Alexandre Dayer; Maria Del Zompo; J. Raymond DePaulo; Bruno Étain; Stephane Jamain; Peter Falkai; Andreas J. Forstner; Louise Frisen; Mark A. Frye; Janice M. Fullerton; Sébastien Gard; Julie S. Garnham; Fernando S. Goes; Maria Grigoroiu-Serbanescu; Paul Grof; Ryota Hashimoto; Joanna Hauser; Stefan Herms; Per Hoffmann; Esther Jiménez; Jean-Pierre Kahn; Layla Kassem; Po-Hsiu Kuo; Tadafumi Kato; John R. Kelsoe; Sarah Kittel-Schneider; Ewa Ferensztajn-Rochowiak; Barbara König; Ichiro Kusumi; Gonzalo Laje; Mikael Landén; Catharina Lavebratt; Susan G. Leckband; Alfonso Tortorella; Mirko Manchia; Lina Martinsson; Michael J. McCarthy; Susan L. McElroy; Francesc Colom; Vincent Millischer; Marina Mitjans; Francis M. Mondimore; Palmiero Monteleone; Caroline M. Nievergelt; Markus M. Nöthen; Tomas Novák; Claire O’Donovan; Norio Ozaki; Urban Ösby; Andrea Pfennig; James B. Potash; Andreas Reif; Eva Reininghaus; Guy A. Rouleau; Janusz K. Rybakowski; Martin Schalling; Peter R. Schofield; Barbara W. Schweizer; Giovanni Severino; Paul D. Shilling; Katzutaka Shimoda; Christian Simhandl; Claire M. Slaney; Claudia Pisanu; Alessio Squassina; Thomas Stamm; Pavla Stopkova; Mario Maj; Gustavo Turecki; Eduard Vieta; Julia Veeh; Stephanie H. Witt; Adam Wright; Peter P. Zandi; Philip B. Mitchell; Michael Bauer; Martin Alda; Marcella Rietschel; Francis J. McMahon; Thomas G. Schulze; Jean-Louis Spadoni; Wahid Boukouaci; Jean-Romain Richard; Philippe Le Corvoisier; Caroline Barrau; Jean-François Zagury; Marion Leboyer; Ryad Tamouza
Source
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients stratification are still needed. A GWAS performed by the International Consortium on Lithium Genetics (ConLiGen) has recently identified genetic markers associated with treatment responses to Li in the human leukocyte antigens (HLA) region. To better understand the molecular mechanisms underlying this association, we have genetically imputed the classical alleles of the HLA region in the European patients of the ConLiGen cohort. We found our best signal for amino-acid variants belonging to the HLA-DRB1*11:01 classical allele, associated with a better response to Li (p