학술논문

An Explainable AI System for the Diagnosis of High-Dimensional Biomedical Data
Document Type
article
Source
BioMedInformatics, Vol 4, Iss 1, Pp 197-218 (2024)
Subject
explainable AI
expert system
symbolic system
biomedical data
flow cytometry data analysis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Computer applications to medicine. Medical informatics
R858-859.7
Language
English
ISSN
2673-7426
Abstract
Typical state-of-the-art flow cytometry data samples typically consist of measures of 10 to 30 features of more than 100,000 cell “events”. Artificial intelligence (AI) systems are able to diagnose such data with almost the same accuracy as human experts. However, such systems face one central challenge: their decisions have far-reaching consequences for the health and lives of people. Therefore, the decisions of AI systems need to be understandable and justifiable by humans. In this work, we present a novel explainable AI (XAI) method called algorithmic population descriptions (ALPODS), which is able to classify (diagnose) cases based on subpopulations in high-dimensional data. ALPODS is able to explain its decisions in a form that is understandable to human experts. For the identified subpopulations, fuzzy reasoning rules expressed in the typical language of domain experts are generated. A visualization method based on these rules allows human experts to understand the reasoning used by the AI system. A comparison with a selection of state-of-the-art XAI systems shows that ALPODS operates efficiently on known benchmark data and on everyday routine case data.