학술논문
Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer
Document Type
article
Author
Aida Ferreiro-Iglesias; James D. McKay; Nicole Brenner; Shama Virani; Corina Lesseur; Valerie Gaborieau; Andy R. Ness; Rayjean J. Hung; Geoffrey Liu; Brenda Diergaarde; Andrew F. Olshan; Neil Hayes; Mark C. Weissler; Lea Schroeder; Noemi Bender; Michael Pawlita; Steve Thomas; Miranda Pring; Tom Dudding; Beatriz Kanterewicz; Robert Ferris; Sera Thomas; Yonathan Brhane; Virginia Díez-Obrero; Maja Milojevic; Karl Smith-Byrne; Daniela Mariosa; Mattias J. Johansson; Rolando Herrero; Stefania Boccia; Gabriella Cadoni; Martin Lacko; Ivana Holcátová; Wolfgang Ahrens; Pagona Lagiou; Areti Lagiou; Jerry Polesel; Lorenzo Simonato; Franco Merletti; Claire M. Healy; Bo T. Hansen; Mari Nygård; David I. Conway; Sylvia Wright; Tatiana V. Macfarlane; Max Robinson; Laia Alemany; Antonio Agudo; Ariana Znaor; Christopher I. Amos; Tim Waterboer; Paul Brennan
Source
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Genetic susceptibility loci for oropharyngeal cancer have been reported but these studies have not always examined human papillomavirus (HPV) status. Here, the authors perform genome-wide analysis taking into account HPV16 serology status and report two independent loci in the HLA region, suggesting the protective role of HLA variants against HPV infection.