학술논문
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
Document Type
article
Author
Source
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Mutations in the BAF SWI/SNF complex subunits are frequent in cancers but selective therapeutic approaches are not available yet. Here, the authors demonstrate that defects ofARID1Aand other subunits sensitizes cancer cells to the DNA checkpoint kinase inhibitor ATR in a synthetic lethal manner.