학술논문
Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
Document Type
article
Author
Indu Kohaar; Xijun Zhang; Shyh-Han Tan; Darryl Nousome; Kevin Babcock; Lakshmi Ravindranath; Gauthaman Sukumar; Elisa Mcgrath-Martinez; John Rosenberger; Camille Alba; Amina Ali; Denise Young; Yongmei Chen; Jennifer Cullen; Inger L. Rosner; Isabell A. Sesterhenn; Albert Dobi; Gregory Chesnut; Clesson Turner; Clifton Dalgard; Matthew D. Wilkerson; Harvey B. Pollard; Shiv Srivastava; Gyorgy Petrovics
Source
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
DNA damage repair genes have been linked with increased aggressiveness of prostate cancer, however, the extent of mutation of these genes has not been analyzed within a cohort of African American patients. Here, the authors identify increased mutation rates in specific DNA repair genes, compared with prostate cancer patients with European Ancestry.