학술논문
Phylogeography of Dengue Virus Serotype 4, Brazil, 2010–2011
Document Type
article
Author
Marcio Roberto Teixeira Nunes; Nuno Rodrigues Faria; Helena Baldez Vasconcelos; Daniele Barbosa de Almeida Medeiros; Clayton Pereira Silva de Lima; Valéria Lima Carvalho; Eliana Vieira Pinto da Silva; Jedson Ferreira Cardoso; Edivaldo Costa Sousa; Keley Nascimento Barbosa Nunes; Sueli Guerreiro Rodrigues; Ana Barroso Abecasis; Marc A. Suchard; Philippe Lemey; Pedro Fernando da Costa Vasconcelos
Source
Emerging Infectious Diseases, Vol 18, Iss 11, Pp 1858-1864 (2012)
Subject
Language
English
ISSN
1080-6040
1080-6059
1080-6059
Abstract
Dengue virus serotype 4 (DENV-4) reemerged in Roraima State, Brazil, 28 years after it was last detected in the country in 1982. To study the origin and evolution of this reemergence, full-length sequences were obtained for 16 DENV-4 isolates from northern (Roraima, Amazonas, Pará States) and northeastern (Bahia State) Brazil during the 2010 and 2011 dengue virus seasons and for an isolate from the 1982 epidemic in Roraima. Spatiotemporal dynamics of DENV-4 introductions in Brazil were applied to envelope genes and full genomes by using Bayesian phylogeographic analyses. An introduction of genotype I into Brazil from Southeast Asia was confirmed, and full genome phylogeographic analyses revealed multiple introductions of DENV-4 genotype II in Brazil, providing evidence for >3 introductions of this genotype within the last decade: 2 from Venezuela to Roraima and 1 from Colombia to Amazonas. The phylogeographic analysis of full genome data has demonstrated the origins of DENV-4 throughout Brazil.