학술논문
SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication
Document Type
article
Author
Source
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
To ensure genome stability, cells need to restrict DNA replication to once per cell cycle. Here the authors show that Cyclin F interacts with and targets the licensing factor CDC6 for degradation, preventing re-firing of replication origins.