학술논문
ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma
Document Type
article
Author
Kavita Praveen; Gaurang C. Patel; Lauren Gurski; Ariane H. Ayer; Trikaladarshi Persaud; Matthew D. Still; Lawrence Miloscio; Tavé Van Zyl; Silvio Alessandro Di Gioia; Ben Brumpton; Kristi Krebs; Bjørn Olav Åsvold; Esteban Chen; Venkata R. M. Chavali; Wen Fury; Harini V. Gudiseva; Sarah Hyde; Eric Jorgenson; Stephanie Lefebvre; Dadong Li; Alexander Li; James Mclninch; Brijeshkumar Patel; Jeremy S. Rabinowitz; Rebecca Salowe; Claudia Schurmann; Anne-Sofie Seidelin; Eli Stahl; Dylan Sun; Tanya M. Teslovich; Anne Tybjærg-Hansen; Cristen Willer; Scott Waldron; Sabrina Walley; Hua Yang; Sarthak Zaveri; Regeneron Genetics Center; GHS-RGC DiscovEHR Collaboration; Estonian Biobank Research Team; Ying Hu; Kristian Hveem; Olle Melander; Lili Milani; Stefan Stender; Joan M. O’Brien; Marcus B. Jones; Gonçalo R. Abecasis; Michael N. Cantor; Jonathan Weyne; Katia Karalis; Aris Economides; Giusy Della Gatta; Manuel A. Ferreira; George D. Yancopoulos; Aris Baras; Carmelo Romano; Giovanni Coppola
Source
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2399-3642
Abstract
Rare variant association data from human genetics combined with in vitro and in vivo functional validation highlight ANGPTL7 as a promising therapeutic target for intraocular pressure reduction, and protection from glaucoma.