학술논문
Combined 18F‐FDG PET‐CT markers in dementia with Lewy bodies
Document Type
article
Author
Maria Vittoria Mattoli; Fabrizio Cocciolillo; Piero Chiacchiaretta; Francesco Dotta; Gianluca Trevisi; Claudia Carrarini; Astrid Thomas; Stefano Sensi; Andrea Delli Pizzi; Angelo Domenico Di Nicola; Adolfo Di Crosta; Nicola Mammarella; Alessandro Padovani; Andrea Pilotto; Fabio Moda; Pietro Tiraboschi; Gianluigi Martino; Laura Bonanni
Source
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 4, Pp n/a-n/a (2023)
Subject
Language
English
ISSN
2352-8729
Abstract
Abstract INTRODUCTION 18F‐Fluoro‐deoxyglucose–positron emission tomography (FDG‐PET) is a supportive biomarker in dementia with Lewy bodies (DLB) diagnosis and its advanced analysis methods, including radiomics and machine learning (ML), were developed recently. The aim of this study was to evaluate the FDG‐PET diagnostic performance in predicting a DLB versus Alzheimer's disease (AD) diagnosis. METHODS FDG‐PET scans were visually and semi‐quantitatively analyzed in 61 patients. Radiomics and ML analyses were performed, building five ML models: (1) clinical features; (2) visual and semi‐quantitative PET features; (3) radiomic features; (4) all PET features; and (5) overall features. RESULTS At follow‐up, 34 patients had DLB and 27 had AD. At visual analysis, DLB PET signs were significantly more frequent in DLB, having the highest diagnostic accuracy (86.9%). At semi‐quantitative analysis, the right precuneus, superior parietal, lateral occipital, and primary visual cortices showed significantly reduced uptake in DLB. The ML model 2 had the highest diagnostic accuracy (84.3%). DISCUSSION FDG‐PET is a valuable tool in DLB diagnosis, having visual and semi‐quantitative analyses with the highest diagnostic accuracy at ML analyses.