학술논문
Healthy lifestyle and genomic ancestry related to good glycemic control in type 1 diabetes patients from Northeastern Brazil: a hierarchical analysis
Document Type
article
Author
Rossana Santiago de Sousa Azulay; Vandilson Rodrigues; Joana D’Arc Matos França de Abreu; Ana Gregória Ferreira Pereira de Almeida; Débora Lago; Maria da Glória Tavares; Gilvan Nascimento; Viviane Rocha; Marcelo Magalhães; Alexandre Facundo; Clariano Pires de Oliveira Neto; Adriana Guimarães Sá; Conceição Ribeiro Veiga Parente; Dayse Aparecida Silva; Marília Brito Gomes; Manuel dos Santos Faria
Source
Frontiers in Endocrinology, Vol 14 (2023)
Subject
Language
English
ISSN
1664-2392
Abstract
IntroductionThis study aimed to investigate the sociodemographic factors, dietary adherence, regular physical activity, and genomic ancestry percentage associated with good glycemic control in Brazilian patients with type 1 diabetes (T1D) using a hierarchical approach.MethodsA cross-sectional study was conducted in 152 T1D patients. Glycated hemoglobin (HbA1C) levels were measured to evaluate the glycemic control status (good, moderate, or poor). Independent factors included sex, age, self-reported skin color, educational level, family income, dietary patterns, and physical activity. The percentage of genomic ancestry (Native American, European, and African) was influenced by a panel of 46 autosomal insertion/deletion ancestry markers. Statistical analyses included receiver operating characteristic curves, and hierarchical logistic regression analysis.ResultsThe hierarchical analysis, patients who had high dietary adherence showed a positive association with good glycemic control (adjustedOR = 2.56, 95% CI:1.18-5.59, P = 0.016). Thus, age greater than 40 years was associated with good glycemic control compared to the children and adolescents group (adjustedOR = 4.55, 95% CI:1.14-18.1, P = 0.031). Males were associated with good glycemic control (adjustedOR = 2.00, 95% CI:1.01-4.00, P =0.047).ConclusionThe study findings suggest that consistent adherence to dietary regimens is associated with good glycemic control after adjusting for sociodemographic and genomic ancestry factors in an admixed population of T1D patients from Northeast Brazil.