학술논문
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS
Document Type
article
Author
María C. García-Hidalgo; Jessica González; Iván D. Benítez; Paola Carmona; Sally Santisteve; Manel Pérez-Pons; Anna Moncusí-Moix; Clara Gort-Paniello; Fátima Rodríguez-Jara; Marta Molinero; Thalia Belmonte; Gerard Torres; Gonzalo Labarca; Estefania Nova-Lamperti; Jesús Caballero; Jesús F. Bermejo-Martin; Adrián Ceccato; Laia Fernández-Barat; Ricard Ferrer; Dario Garcia-Gasulla; Rosario Menéndez; Ana Motos; Oscar Peñuelas; Jordi Riera; Antoni Torres; Ferran Barbé; David de Gonzalo-Calvo
Source
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 1537-1549 (2022)
Subject
Language
English
ISSN
22221751
2222-1751
2222-1751
Abstract
There is a limited understanding of the pathophysiology of postacute pulmonary sequelae in severe COVID-19. The aim of current study was to define the circulating microRNA (miRNA) profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDS. The study included patients who developed ARDS secondary to SARS-CoV-2 infection (n = 167) and a group of infected patients who did not develop ARDS (n = 33). Patients were evaluated 3 months after hospital discharge. The follow-up included a complete pulmonary evaluation and chest computed tomography. Plasma miRNA profiling was performed using RT-qPCR. Random forest was used to construct miRNA signatures associated with lung diffusing capacity for carbon monoxide (DLCO) and total severity score (TSS). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were conducted. DLCO