학술논문
A comprehensive re-assessment of the association between vitamin D and cancer susceptibility using Mendelian randomization
Document Type
article
Author
Jue-Sheng Ong; Suzanne C. Dixon-Suen; Xikun Han; Jiyuan An; Esophageal Cancer Consortium; and Me Research Team; Upekha Liyanage; Jean-Cluade Dusingize; Johannes Schumacher; Ines Gockel; Anne Böhmer; Janusz Jankowski; Claire Palles; Tracy O’Mara; Amanda Spurdle; Matthew H. Law; Mark M. Iles; Paul Pharoah; Andrew Berchuck; Wei Zheng; Aaron P. Thrift; Catherine Olsen; Rachel E. Neale; Puya Gharahkhani; Penelope M. Webb; Stuart MacGregor
Source
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Studies of the genetic association between vitamin D and cancer risk have typically been underpowered. Here the authors analyse this using Mendelian Randomisation with more than 70 vitamin D variants obtained from the UK Biobank and large-scale data from various consortia, confirming null associations between vitamin D and most cancers.