학술논문
Mapping the epigenetic modifications of DNA and RNA
Document Type
article
Author
Source
Protein & Cell, Vol 11, Iss 11, Pp 792-808 (2020)
Subject
Language
English
ISSN
1674-800X
1674-8018
1674-8018
Abstract
Abstract Over 17 and 160 types of chemical modifications have been identified in DNA and RNA, respectively. The interest in understanding the various biological functions of DNA and RNA modifications has lead to the cutting-edged fields of epigenomics and epitranscriptomics. Developing chemical and biological tools to detect specific modifications in the genome or transcriptome has greatly facilitated their study. Here, we review the recent technological advances in this rapidly evolving field. We focus on high-throughput detection methods and biological findings for these modifications, and discuss questions to be addressed as well. We also summarize third-generation sequencing methods, which enable long-read and single-molecule sequencing of DNA and RNA modification.