학술논문
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Document Type
article
Author
Sonia Shah; Albert Henry; Carolina Roselli; Honghuang Lin; Garðar Sveinbjörnsson; Ghazaleh Fatemifar; Åsa K. Hedman; Jemma B. Wilk; Michael P. Morley; Mark D. Chaffin; Anna Helgadottir; Niek Verweij; Abbas Dehghan; Peter Almgren; Charlotte Andersson; Krishna G. Aragam; Johan Ärnlöv; Joshua D. Backman; Mary L. Biggs; Heather L. Bloom; Jeffrey Brandimarto; Michael R. Brown; Leonard Buckbinder; David J. Carey; Daniel I. Chasman; Xing Chen; Xu Chen; Jonathan Chung; William Chutkow; James P. Cook; Graciela E. Delgado; Spiros Denaxas; Alexander S. Doney; Marcus Dörr; Samuel C. Dudley; Michael E. Dunn; Gunnar Engström; Tõnu Esko; Stephan B. Felix; Chris Finan; Ian Ford; Mohsen Ghanbari; Sahar Ghasemi; Vilmantas Giedraitis; Franco Giulianini; John S. Gottdiener; Stefan Gross; Daníel F. Guðbjartsson; Rebecca Gutmann; Christopher M. Haggerty; Pim van der Harst; Craig L. Hyde; Erik Ingelsson; J. Wouter Jukema; Maryam Kavousi; Kay-Tee Khaw; Marcus E. Kleber; Lars Køber; Andrea Koekemoer; Claudia Langenberg; Lars Lind; Cecilia M. Lindgren; Barry London; Luca A. Lotta; Ruth C. Lovering; Jian’an Luan; Patrik Magnusson; Anubha Mahajan; Kenneth B. Margulies; Winfried März; Olle Melander; Ify R. Mordi; Thomas Morgan; Andrew D. Morris; Andrew P. Morris; Alanna C. Morrison; Michael W. Nagle; Christopher P. Nelson; Alexander Niessner; Teemu Niiranen; Michelle L. O’Donoghue; Anjali T. Owens; Colin N. A. Palmer; Helen M. Parry; Markus Perola; Eliana Portilla-Fernandez; Bruce M. Psaty; Regeneron Genetics Center; Kenneth M. Rice; Paul M. Ridker; Simon P. R. Romaine; Jerome I. Rotter; Perttu Salo; Veikko Salomaa; Jessica van Setten; Alaa A. Shalaby; Diane T. Smelser; Nicholas L. Smith; Steen Stender; David J. Stott; Per Svensson; Mari-Liis Tammesoo; Kent D. Taylor; Maris Teder-Laving; Alexander Teumer; Guðmundur Thorgeirsson; Unnur Thorsteinsdottir; Christian Torp-Pedersen; Stella Trompet; Benoit Tyl; Andre G. Uitterlinden; Abirami Veluchamy; Uwe Völker; Adriaan A. Voors; Xiaosong Wang; Nicholas J. Wareham; Dawn Waterworth; Peter E. Weeke; Raul Weiss; Kerri L. Wiggins; Heming Xing; Laura M. Yerges-Armstrong; Bing Yu; Faiez Zannad; Jing Hua Zhao; Harry Hemingway; Nilesh J. Samani; John J. V. McMurray; Jian Yang; Peter M. Visscher; Christopher Newton-Cheh; Anders Malarstig; Hilma Holm; Steven A. Lubitz; Naveed Sattar; Michael V. Holmes; Thomas P. Cappola; Folkert W. Asselbergs; Aroon D. Hingorani; Karoline Kuchenbaecker; Patrick T. Ellinor; Chim C. Lang; Kari Stefansson; J. Gustav Smith; Ramachandran S. Vasan; Daniel I. Swerdlow; R. Thomas Lumbers
Source
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Heart failure is a complex syndrome that is associated with many different underlying risk factors. Here, to increase power, the authors jointly analyse cases of heart failure of different aetiologies in a genome-wide association study and identify 11 loci of which ten had not been previously reported.