학술논문
Applications of machine learning in decision analysis for dose management for dofetilide.
Document Type
article
Author
Source
PLoS ONE, Vol 14, Iss 12, p e0227324 (2019)
Subject
Language
English
ISSN
1932-6203
Abstract
BACKGROUND:Initiation of the antiarrhythmic medication dofetilide requires an FDA-mandated 3 days of telemetry monitoring due to heightened risk of toxicity within this time period. Although a recommended dose management algorithm for dofetilide exists, there is a range of real-world approaches to dosing the medication. METHODS AND RESULTS:In this multicenter investigation, clinical data from the Antiarrhythmic Drug Genetic (AADGEN) study was examined for 354 patients undergoing dofetilide initiation. Univariate logistic regression identified a starting dofetilide dose of 500 mcg (OR 5.0, 95%CI 2.5-10.0, p