학술논문
Associations of body size with all-cause and cause-specific mortality in healthy older adults
Document Type
article
Author
Prudence R. Carr; Katherine L. Webb; Johannes T. Neumann; Le T. P. Thao; Lawrence J. Beilin; Michael E. Ernst; Bernadette Fitzgibbon; Danijela Gasevic; Mark R. Nelson; Anne B. Newman; Suzanne G. Orchard; Alice Owen; Christopher M. Reid; Nigel P. Stocks; Andrew M. Tonkin; Robyn L. Woods; John J. McNeil
Source
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract In the general population, body mass index (BMI) and waist circumference are recognized risk factors for several chronic diseases and all-cause mortality. However, whether these associations are the same for older adults is less clear. The association of baseline BMI and waist circumference with all-cause and cause-specific mortality was investigated in 18,209 Australian and US participants (mean age: 75.1 ± 4.5 years) from the ASPirin in Reducing Events in the Elderly (ASPREE) study, followed up for a median of 6.9 years (IQR: 5.7, 8.0). There were substantially different relationships observed in men and women. In men, the lowest risk of all-cause and cardiovascular mortality was observed with a BMI in the range 25.0–29.9 kg/m2 [HR25-29.9 vs 21–24.9 kg/m 2: 0.85; 95% CI, 0.73–1.00] while the highest risk was in those who were underweight [HRBMI