학술논문
Proteasome inhibitor-induced modulation reveals the spliceosome as a specific therapeutic vulnerability in multiple myeloma
Document Type
article
Author
Hector H. Huang; Ian D. Ferguson; Alexis M. Thornton; Prabhakar Bastola; Christine Lam; Yu-Hsiu T. Lin; Priya Choudhry; Margarette C. Mariano; Makeba D. Marcoulis; Chin Fen Teo; Julia Malato; Paul J. Phojanakong; Thomas G. Martin; Jeffrey L. Wolf; Sandy W. Wong; Nina Shah; Byron Hann; Angela N. Brooks; Arun P. Wiita
Source
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
The mechanisms of action of proteasome inhibitors (PI) in multiple myeloma (MM) treatment are not fully elucidated. Here, the authors use unbiased phosphoproteomics in PI-treated MM and show increased phosphorylation of splicing-associated proteins, ultimately revealing splicing interference as a mode of PI action as well as demonstrating the spliceosome as a specific therapeutic vulnerability in this disease.