학술논문
Genome-wide interaction study of dietary intake of fibre, fruits, and vegetables with risk of colorectal cancerResearch in context
Document Type
article
Author
Nikos Papadimitriou; Andre Kim; Eric S. Kawaguchi; John Morrison; Virginia Diez-Obrero; Demetrius Albanes; Sonja I. Berndt; Stéphane Bézieau; Stephanie A. Bien; D Timothy Bishop; Emmanouil Bouras; Hermann Brenner; Daniel D. Buchanan; Peter T. Campbell; Robert Carreras-Torres; Andrew T. Chan; Jenny Chang-Claude; David V. Conti; Matthew A. Devall; Niki Dimou; David A. Drew; Stephen B. Gruber; Tabitha A. Harrison; Michael Hoffmeister; Jeroen R. Huyghe; Amit D. Joshi; Temitope O. Keku; Anshul Kundaje; Sébastien Küry; Loic Le Marchand; Juan Pablo Lewinger; Li Li; Brigid M. Lynch; Victor Moreno; Christina C. Newton; Mireia Obón-Santacana; Jennifer Ose; Andrew J. Pellatt; Anita R. Peoples; Elizabeth A. Platz; Conghui Qu; Gad Rennert; Edward Ruiz-Narvaez; Anna Shcherbina; Mariana C. Stern; Yu-Ru Su; Duncan C. Thomas; Claire E. Thomas; Yu Tian; Konstantinos K. Tsilidis; Cornelia M. Ulrich; Caroline Y. Um; Kala Visvanathan; Jun Wang; Emily White; Michael O. Woods; Stephanie L. Schmit; Finlay Macrae; John D. Potter; John L. Hopper; Ulrike Peters; Neil Murphy; Li Hsu; Marc J. Gunter; W. James Gauderman
Source
EBioMedicine, Vol 104, Iss , Pp 105146- (2024)
Subject
Language
English
ISSN
2352-3964
Abstract
Summary: Background: Consumption of fibre, fruits and vegetables have been linked with lower colorectal cancer (CRC) risk. A genome-wide gene-environment (G × E) analysis was performed to test whether genetic variants modify these associations. Methods: A pooled sample of 45 studies including up to 69,734 participants (cases: 29,896; controls: 39,838) of European ancestry were included. To identify G × E interactions, we used the traditional 1--degree-of-freedom (DF) G × E test and to improve power a 2-step procedure and a 3DF joint test that investigates the association between a genetic variant and dietary exposure, CRC risk and G × E interaction simultaneously. Findings: The 3-DF joint test revealed two significant loci with p-value