학술논문
Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy
Document Type
article
Author
Gabriela Hjell; Jaroslav Rokicki; Attila Szabo; René Holst; Natalia Tesli; Christina Bell; Thomas Fischer-Vieler; Maren Caroline Frogner Werner; Synve Hoffart Lunding; Monica Bettina Elkjær Greenwood Ormerod; Ingrid Torp Johansen; Srdjan Djurovic; Thor Ueland; Ole Andreas Andreassen; Ingrid Melle; Trine Vik Lagerberg; Lynn Mørch-Johnsen; Nils Eiel Steen; Unn Kristin Haukvik
Source
BMC Psychiatry, Vol 23, Iss 1, Pp 1-11 (2023)
Subject
Language
English
ISSN
1471-244X
Abstract
Abstract Background Impulsivity is a transdiagnostic feature linked to severe clinical expression and a potential target for psychopharmacological strategies. Biological underpinnings are largely unknown, but involvement of immune dysregulation has been indicated, and the effects of psychopharmacological agents vary. We investigated if impulsivity was associated with circulating immune marker levels and with a range of psychopharmacological treatment regimens in severe mental disorders. Methods Impulsivity was assessed in a sample (N = 657) of patients with schizophrenia or schizophreniform disorder (SCZ) (N = 116) or bipolar disorder (BD) (N = 159) and healthy participants (N = 382) using the Barratt Impulsiveness Scale (BIS-11) questionnaire. Plasma levels of systemic immune markers (RANTES, IL-1RA, IL-18, IL-18BP, sTNFR-1) were measured by enzyme immunoassays. Patients underwent thorough clinical assessment, including evaluation of psychotropic medication. Associations were assessed using linear regressions. Results Impulsivity was positively associated with SCZ (p