학술논문
Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome
Document Type
article
Author
Mariann Gyöngyösi; Dominika Lukovic; Julia Mester-Tonczar; Katrin Zlabinger; Patrick Einzinger; Andreas Spannbauer; Victor Schweiger; Katharina Schefberger; Eslam Samaha; Jutta Bergler-Klein; Martin Riesenhuber; Christian Nitsche; Christian Hengstenberg; Patrick Mucher; Helmuth Haslacher; Monika Breuer; Robert Strassl; Elisabeth Puchhammer-Stöckl; Christian Loewe; Dietrich Beitzke; Ena Hasimbegovic; Thomas A. Zelniker
Source
npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)
Subject
Language
English
ISSN
2059-0105
Abstract
Abstract Epstein–Barr virus (EBV) reactivation may be involved in long-COVID symptoms, but reactivation of other viruses as a factor has received less attention. Here we evaluated the reactivation of parvovirus-B19 and several members of the Herpesviridae family (DNA viruses) in patients with long-COVID syndrome. We hypothesized that monovalent COVID-19 vaccines inhibit viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome, thereby reducing clinical symptoms. Clinical and laboratory data for 252 consecutive patients with PCR-verified past SARS-CoV-2 infection and long-COVID syndrome (155 vaccinated and 97 non-vaccinated) were recorded during April 2021–May 2022 (median 243 days post-COVID-19 infection). DNA virus–related IgG and IgM titers were compared between vaccinated and non-vaccinated long-COVID patients and with age- and sex-matched non-infected, unvaccinated (pan-negative for spike-antibody) controls. Vaccination with monovalent COVID-19 vaccines was associated with significantly less frequent fatigue and multiorgan symptoms (p