학술논문
Blood virosphere in febrile Tanzanian children
Document Type
article
Author
Samuel Cordey; Florian Laubscher; Mary-Anne Hartley; Thomas Junier; Kristina Keitel; Mylène Docquier; Nicolas Guex; Christian Iseli; Gael Vieille; Philippe Le Mercier; Anne Gleizes; Josephine Samaka; Tarsis Mlaganile; Frank Kagoro; John Masimba; Zamzam Said; Hosiana Temba; Gasser H. Elbanna; Caroline Tapparel; Marie-Celine Zanella; Ioannis Xenarios; Jacques Fellay; Valérie D’Acremont; Laurent Kaiser
Source
Emerging Microbes and Infections, Vol 10, Iss 1, Pp 982-993 (2021)
Subject
Language
English
ISSN
22221751
2222-1751
2222-1751
Abstract
Viral infections are the leading cause of childhood acute febrile illnesses motivating consultation in sub-Saharan Africa. The majority of causal viruses are never identified in low-resource clinical settings as such testing is either not part of routine screening or available diagnostic tools have limited ability to detect new/unexpected viral variants. An in-depth exploration of the blood virome is therefore necessary to clarify the potential viral origin of fever in children. Metagenomic next-generation sequencing is a powerful tool for such broad investigations, allowing the detection of RNA and DNA viral genomes. Here, we describe the blood virome of 816 febrile children (