학술논문
The genomic and transcriptional landscape of primary central nervous system lymphoma
Document Type
article
Author
Josefine Radke; Naveed Ishaque; Randi Koll; Zuguang Gu; Elisa Schumann; Lina Sieverling; Sebastian Uhrig; Daniel Hübschmann; Umut H. Toprak; Cristina López; Xavier Pastor Hostench; Simone Borgoni; Dilafruz Juraeva; Fabienne Pritsch; Nagarajan Paramasivam; Gnana Prakash Balasubramanian; Matthias Schlesner; Shashwat Sahay; Marc Weniger; Debora Pehl; Helena Radbruch; Anja Osterloh; Agnieszka Korfel; Martin Misch; Julia Onken; Katharina Faust; Peter Vajkoczy; Dag Moskopp; Yawen Wang; Andreas Jödicke; Lorenz Trümper; Ioannis Anagnostopoulos; Dido Lenze; Ralf Küppers; Michael Hummel; Clemens A. Schmitt; Otmar D. Wiestler; Stephan Wolf; Andreas Unterberg; Roland Eils; Christel Herold-Mende; Benedikt Brors; ICGC MMML-Seq Consortium; Reiner Siebert; Stefan Wiemann; Frank L. Heppner
Source
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Primary lymphomas of the central nervous system (PCNSL) are defined as diffuse large B-cell lymphomas (DLBCL) confined to the CNS. Here, the authors complete whole genome sequencing and RNA-seq to characterize 51 PCNSLs, and find common mutations in immune pathways and upregulated TERT expression and find distinct pathway differences between DLBCL and other primary CNS lymphomas.