학술논문
A versatile soluble siglec scaffold for sensitive and quantitative detection of glycan ligands
Document Type
article
Author
Emily Rodrigues; Jaesoo Jung; Heajin Park; Caleb Loo; Sepideh Soukhtehzari; Elena N. Kitova; Fahima Mozaneh; Gour Daskhan; Edward N. Schmidt; Vivian Aghanya; Susmita Sarkar; Laura Streith; Chris D. St. Laurent; Linh Nguyen; Jean-Philippe Julien; Lori J. West; Karla C. Williams; John S. Klassen; Matthew S. Macauley
Source
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunomodulatory receptors expressed on cells of the hematopoietic lineage. Here the authors demonstrate an approach for the identification of the glycan ligands of Siglecs, which is also applicable to other families of glycan-binding proteins.