학술논문
Genetic susceptibility to hepatocellular carcinoma in chromosome 22q13.31, findings of a genome‐wide association study
Document Type
article
Author
Zhanwei Wang; Anuradha S Budhu; Yi Shen; Linda Lou Wong; Brenda Y Hernandez; Maarit Tiirikainen; Xiaomei Ma; Melinda L Irwin; Lingeng Lu; Hongyu Zhao; Joseph K Lim; Tamar Taddei; Lopa Mishra; Karen Pawlish; Antoinette Stroup; Robert Brown; Mindie H Nguyen; Jill Koshiol; Maria O Hernandez; Marshonna Forgues; Hwai‐I Yang; Mei‐Hsuan Lee; Yu‐Han Huang; Motoki Iwasaki; Atsushi Goto; Shiori Suzuki; Koichi Matsuda; Chizu Tanikawa; Yoichiro Kamatani; Dean Mann; Maria Guarnera; Kirti Shetty; Claire E Thomas; Jian‐Min Yuan; Chiea Chuen Khor; Woon‐Puay Koh; Harvey Risch; Xin Wei Wang; Herbert Yu
Source
JGH Open, Vol 5, Iss 12, Pp 1363-1372 (2021)
Subject
Language
English
ISSN
2397-9070
Abstract
Abstract Background and Aim Chronic hepatitis C virus (HCV) infection, long‐term alcohol use, cigarette smoking, and obesity are the major risk factors for hepatocellular carcinoma (HCC) in the United States, but the disease risk varies substantially among individuals with these factors, suggesting host susceptibility to and gene–environment interactions in HCC. To address genetic susceptibility to HCC, we conducted a genome‐wide association study (GWAS). Methods Two case‐control studies on HCC were conducted in the United States. DNA samples were genotyped using the Illumian microarray chip with over 710 000 single nucleotide polymorphisms (SNPs). We compared these SNPs between 705 HCC cases and 1455 population controls for their associations with HCC and verified our findings in additional studies. Results In this GWAS, we found that two SNPs were associated with HCC at P