학술논문
Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas
Document Type
article
Author
Source
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Galectins are carbohydrate binding proteins previously implicated in sensing and repairing damaged lysosomes. Here, the authors show that galectin-9 has specific lysosomal roles in autophagy and contributes to cell degeneration and apoptosis in colitis and pancreatitis in mice.