학술논문
Reprogramming of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma
Document Type
article
Author
Katrin Rabold; Martijn Zoodsma; Inge Grondman; Yunus Kuijpers; Manita Bremmers; Martin Jaeger; Bowen Zhang; Willemijn Hobo; Han J. Bonenkamp; Johannes H. W. de Wilt; Marcel J. R. Janssen; Lenneke A. M. Cornelissen; Ilse C. H. van Engen-van Grunsven; Willem J. M. Mulder; Jan W. A. Smit; Gosse J. Adema; Mihai G. Netea; Yang Li; Cheng-Jian Xu; Romana T. Netea-Maier
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Myeloid cells contribute to the tumor microenvironment of thyroid cancers, but their functional relevance is lesser known. Here authors show that myeloid cells infiltrating non-medullary thyroid carcinomas upregulate their antigen presentation-related genes, release less cytokines and over-produce reactive oxygen species, with transcriptional changes already present in extra-tumoral myeloid cells.