학술논문
Serum insulin-like growth factor binding protein-3 as a potential biomarker for diagnosis and prognosis of oesophageal squamous cell carcinoma
Document Type
article
Author
Source
Annals of Medicine, Vol 54, Iss 1, Pp 2153-2166 (2022)
Subject
Language
English
ISSN
07853890
1365-2060
0785-3890
1365-2060
0785-3890
Abstract
Background Insulin-like growth factor binding protein-3 (IGFBP3) has been reported to be related to the risk of some cancers. Here we focussed on serum IGFBP3 as a possible biomarker of diagnosis and prognosis for oesophageal squamous carcinoma (ESCC).Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure the serum IGFBP3 level in the training cohort including 136 ESCC patients and 119 normal controls and the validation cohort with 55 ESCC patients and 42 normal controls. The receiver operating characteristics curve (ROC) was used to assess the diagnosis value. Cox proportional hazards model was applied to select factors for survival nomogram construction.Results Serum IGFBP3 levels were significantly lower in early-stage ESCC or ESCC patients than those in normal controls (p