학술논문
Sex differences in febrile children with respiratory symptoms attending European emergency departments: An observational multicenter study.
Document Type
article
Author
Chantal D Tan; Soufiane El Ouasghiri; Ulrich von Both; Enitan D Carrol; Marieke Emonts; Michiel van der Flier; Ronald de Groot; Jethro Herberg; Benno Kohlmaier; Michael Levin; Emma Lim; Ian K Maconochie; Federico Martinon-Torres; Ruud G Nijman; Marko Pokorn; Irene Rivero-Calle; Maria Tsolia; Clementien L Vermont; Werner Zenz; Dace Zavadska; Henriette A Moll; Joany M Zachariasse; PERFORM consortium (Personalised Risk assessment in febrile children to optimise Real-life Management across the European Union)
Source
PLoS ONE, Vol 17, Iss 8, p e0271934 (2022)
Subject
Language
English
ISSN
1932-6203
Abstract
ObjectiveTo assess sex differences in presentation and management of febrile children with respiratory symptoms attending European Emergency Departments.Design and settingAn observational study in twelve Emergency Departments in eight European countries.PatientsPreviously healthy children aged 0-Main outcome measuresThe main outcomes were patient characteristics and management defined as diagnostic tests, treatment and admission. Descriptive statistics were used for patient characteristics and management stratified by sex. Multivariable logistic regression analyses were performed for the association between sex and management with adjustment for age, disease severity and Emergency Department. Additionally, subgroup analyses were performed in children with upper and lower respiratory tract infections and in children below five years.ResultsWe included 19,781 febrile children with respiratory symptoms. The majority were boys (54%), aged 1-5 years (58%) and triaged as low urgent (67%). Girls presented less frequently with tachypnea (15% vs 16%, p = 0.002) and increased work of breathing (8% vs 12%, pConclusionsSex differences concerning presentation and management are present in previously healthy febrile children with respiratory symptoms presenting to the Emergency Department. Future research should focus on whether these differences are related to clinicians' attitudes, differences in clinical symptoms at the time of presentation and disease severity.