학술논문
Therapeutic targeting and rapid mobilization of endosteal HSC using a small molecule integrin antagonist
Document Type
article
Author
Source
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Subject
Language
English
ISSN
2041-1723
Abstract
Mobilizing haematopoietic stem cells to the peripheral blood has largely replaced bone marrow transplants as a strategy in the clinic. Here, Cao et al. report the use of an α9β1/α4β1integrin antagonist to induce rapid mobilization of blood stem cells from the bone marrow in a humanized mouse model.