학술논문
Comprehensive T cell repertoire characterization of non-small cell lung cancer
Document Type
article
Author
Alexandre Reuben; Jiexin Zhang; Shin-Heng Chiou; Rachel M. Gittelman; Jun Li; Won-Chul Lee; Junya Fujimoto; Carmen Behrens; Xiaoke Liu; Feng Wang; Kelly Quek; Chunlin Wang; Farrah Kheradmand; Runzhe Chen; Chi-Wan Chow; Heather Lin; Chantale Bernatchez; Ali Jalali; Xin Hu; Chang-Jiun Wu; Agda Karina Eterovic; Edwin Roger Parra; Erik Yusko; Ryan Emerson; Sharon Benzeno; Marissa Vignali; Xifeng Wu; Yuanqing Ye; Latasha D. Little; Curtis Gumbs; Xizeng Mao; Xingzhi Song; Samantha Tippen; Rebecca L. Thornton; Tina Cascone; Alexandra Snyder; Jennifer A. Wargo; Roy Herbst; Stephen Swisher; Humam Kadara; Cesar Moran; Neda Kalhor; Jianhua Zhang; Paul Scheet; Ara A. Vaporciyan; Boris Sepesi; Don L. Gibbons; Harlan Robins; Patrick Hwu; John V. Heymach; Padmanee Sharma; James P. Allison; Veera Baladandayuthapani; Jack J. Lee; Mark M. Davis; Ignacio I. Wistuba; P. Andrew Futreal; Jianjun Zhang
Source
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Subject
Language
English
ISSN
2041-1723
Abstract
Relevant features of T cell repertoire in human cancer remain to be delineated. Here the authors show, by TCR sequencing in a large cohort of lung cancer patients, that while a majority of T cell clones are shared between tumor and adjacent lung tissue, less frequent tumor-unique T cell clones correlate with worse prognosis.