학술논문
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission
Document Type
article
Author
David A. Baker; Lindsay B. Stewart; Jonathan M. Large; Paul W. Bowyer; Keith H. Ansell; María B. Jiménez-Díaz; Majida El Bakkouri; Kristian Birchall; Koen J. Dechering; Nathalie S. Bouloc; Peter J. Coombs; David Whalley; Denise J. Harding; Ela Smiljanic-Hurley; Mary C. Wheldon; Eloise M. Walker; Johannes T. Dessens; María José Lafuente; Laura M. Sanz; Francisco-Javier Gamo; Santiago B. Ferrer; Raymond Hui; Teun Bousema; Iñigo Angulo-Barturén; Andy T. Merritt; Simon L. Croft; Winston E. Gutteridge; Catherine A. Kettleborough; Simon A. Osborne
Source
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Subject
Language
English
ISSN
2041-1723
48607312
48607312
Abstract
Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to mosquitoes.