학술논문
Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening
Document Type
article
Author
Mario Carucci; Julien Duez; Joel Tarning; Irene García-Barbazán; Aurélie Fricot-Monsinjon; Abdoulaye Sissoko; Lucie Dumas; Pablo Gamallo; Babette Beher; Pascal Amireault; Michael Dussiot; Ming Dao; Mitchell V. Hull; Case W. McNamara; Camille Roussel; Papa Alioune Ndour; Laura Maria Sanz; Francisco Javier Gamo; Pierre Buffet
Source
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Subject
Language
English
ISSN
2041-1723
Abstract
Authors propose their splenic mimetic filtration method, microsphiltration, and utilise this approach in a drug-screen, to identify compounds that induce a stiffening effect on Plasmodium falciparum-infected erythrocytes. They proceed to assess safety and tolerability of one identified compound in a phase I clinical trial.