학술논문
A comprehensive model for assessment of liver stage therapies targeting Plasmodium vivax and Plasmodium falciparum
Document Type
article
Author
Alison Roth; Steven P. Maher; Amy J. Conway; Ratawan Ubalee; Victor Chaumeau; Chiara Andolina; Stephen A. Kaba; Amélie Vantaux; Malina A. Bakowski; Richard Thomson-Luque; Swamy Rakesh Adapa; Naresh Singh; Samantha J. Barnes; Caitlin A. Cooper; Mélanie Rouillier; Case W. McNamara; Sebastian A. Mikolajczak; Noah Sather; Benoît Witkowski; Brice Campo; Stefan H. I. Kappe; David E. Lanar; François Nosten; Silas Davidson; Rays H. Y. Jiang; Dennis E. Kyle; John H. Adams
Source
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Subject
Language
English
ISSN
2041-1723
Abstract
Currently available platforms to study liver stage of Plasmodium species have limitations. Here, the authors show that primary human hepatocyte cultures in 384-well format support hypnozoite and other liver stage development and are suitable for drug and antibody screens.