학술논문
Prenatal exposures to organophosphate ester metabolite mixtures and children’s neurobehavioral outcomes in the MADRES pregnancy cohort
Document Type
article
Author
Ixel Hernandez-Castro; Sandrah P. Eckel; Caitlin G. Howe; Zhongzheng Niu; Kurunthachalam Kannan; Morgan Robinson; Helen B. Foley; Tingyu Yang; Mario J. Vigil; Xinci Chen; Brendan Grubbs; Deborah Lerner; Nathana Lurvey; Laila Al-Marayati; Rima Habre; Genevieve F. Dunton; Shohreh F. Farzan; Max T. Aung; Carrie V. Breton; Theresa M. Bastain
Source
Environmental Health, Vol 22, Iss 1, Pp 1-21 (2023)
Subject
Language
English
ISSN
1476-069X
Abstract
Abstract Background Evidence suggests organophosphate esters (OPEs) are neurotoxic; however, the epidemiological literature remains scarce. We investigated whether prenatal exposures to OPEs were associated with child neurobehavior in the MADRES cohort. Methods We measured nine OPE metabolites in 204 maternal urine samples (gestational age at collection: 31.4 ± 1.8 weeks). Neurobehavior problems were assessed among 36-month-old children using the Child Behavior Checklist’s (CBCL) three composite scales [internalizing, externalizing, and total problems]. We examined associations between tertiles of prenatal OPE metabolites (> 50% detection) and detect/non-detect categories (