학술논문
Infectious stimuli promote malignant B-cell acute lymphoblastic leukemia in the absence of AID
Document Type
article
Author
Guillermo Rodríguez-Hernández; Friederike V. Opitz; Pilar Delgado; Carolin Walter; Ángel F. Álvarez-Prado; Inés González-Herrero; Franziska Auer; Ute Fischer; Stefan Janssen; Christoph Bartenhagen; Javier Raboso-Gallego; Ana Casado-García; Alberto Orfao; Oscar Blanco; Diego Alonso-López; Javier De Las Rivas; Sara González de Tena-Dávila; Markus Müschen; Martin Dugas; Francisco Javier García Criado; María Begoña García Cenador; Carolina Vicente-Dueñas; Julia Hauer; Almudena R. Ramiro; Isidro Sanchez-Garcia; Arndt Borkhardt
Source
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Subject
Language
English
ISSN
2041-1723
Abstract
Infection or chronic inflammation is a risk factor for childhood B-cell precursor acute lymphoblastic leukemia. Here, the authors show that the DNA editing enzyme AID is expressed in infected B cells but using genetic mouse models show that it does not contribute to leukemia pathogenesis.