학술논문
Tau deposition patterns are associated with functional connectivity in primary tauopathies
Document Type
article
Author
Nicolai Franzmeier; Matthias Brendel; Leonie Beyer; Luna Slemann; Gabor G. Kovacs; Thomas Arzberger; Carolin Kurz; Gesine Respondek; Milica J. Lukic; Davina Biel; Anna Rubinski; Lukas Frontzkowski; Selina Hummel; Andre Müller; Anika Finze; Carla Palleis; Emanuel Joseph; Endy Weidinger; Sabrina Katzdobler; Mengmeng Song; Gloria Biechele; Maike Kern; Maximilian Scheifele; Boris-Stephan Rauchmann; Robert Perneczky; Michael Rullman; Marianne Patt; Andreas Schildan; Henryk Barthel; Osama Sabri; Jost J. Rumpf; Matthias L. Schroeter; Joseph Classen; Victor Villemagne; John Seibyl; Andrew W. Stephens; Edward B. Lee; David G. Coughlin; Armin Giese; Murray Grossman; Corey T. McMillan; Ellen Gelpi; Laura Molina-Porcel; Yaroslau Compta; John C. van Swieten; Laura Donker Laat; Claire Troakes; Safa Al-Sarraj; John L. Robinson; Sharon X. Xie; David J. Irwin; Sigrun Roeber; Jochen Herms; Mikael Simons; Peter Bartenstein; Virginia M. Lee; John Q. Trojanowski; Johannes Levin; Günter Höglinger; Michael Ewers
Source
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.