학술논문
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
Document Type
article
Author
Suzanne Vogelezang; Jonathan P Bradfield; Tarunveer S Ahluwalia; John A Curtin; Timo A Lakka; Niels Grarup; Markus Scholz; Peter J van der Most; Claire Monnereau; Evie Stergiakouli; Anni Heiskala; Momoko Horikoshi; Iryna O Fedko; Natalia Vilor-Tejedor; Diana L Cousminer; Marie Standl; Carol A Wang; Jorma Viikari; Frank Geller; Carmen Íñiguez; Niina Pitkänen; Alessandra Chesi; Jonas Bacelis; Loic Yengo; Maties Torrent; Ioanna Ntalla; Øyvind Helgeland; Saskia Selzam; Judith M Vonk; Mohammed H Zafarmand; Barbara Heude; Ismaa Sadaf Farooqi; Akram Alyass; Robin N Beaumont; Christian T Have; Peter Rzehak; Jose Ramon Bilbao; Theresia M Schnurr; Inês Barroso; Klaus Bønnelykke; Lawrence J Beilin; Lisbeth Carstensen; Marie-Aline Charles; Bo Chawes; Karine Clément; Ricardo Closa-Monasterolo; Adnan Custovic; Johan G Eriksson; Joaquin Escribano; Maria Groen-Blokhuis; Veit Grote; Dariusz Gruszfeld; Hakon Hakonarson; Torben Hansen; Andrew T Hattersley; Mette Hollensted; Jouke-Jan Hottenga; Elina Hyppönen; Stefan Johansson; Raimo Joro; Mika Kähönen; Ville Karhunen; Wieland Kiess; Bridget A Knight; Berthold Koletzko; Andreas Kühnapfel; Kathrin Landgraf; Jean-Paul Langhendries; Terho Lehtimäki; Jaakko T Leinonen; Aihuali Li; Virpi Lindi; Estelle Lowry; Mariona Bustamante; Carolina Medina-Gomez; Mads Melbye; Kim F Michaelsen; Camilla S Morgen; Trevor A Mori; Tenna R H Nielsen; Harri Niinikoski; Albertine J Oldehinkel; Katja Pahkala; Kalliope Panoutsopoulou; Oluf Pedersen; Craig E Pennell; Christine Power; Sijmen A Reijneveld; Fernando Rivadeneira; Angela Simpson; Peter D Sly; Jakob Stokholm; Kook K Teo; Elisabeth Thiering; Nicholas J Timpson; André G Uitterlinden; Catharina E M van Beijsterveldt; Barbera D C van Schaik; Marc Vaudel; Elvira Verduci; Rebecca K Vinding; Mandy Vogel; Eleftheria Zeggini; Sylvain Sebert; Mads V Lind; Christopher D Brown; Loreto Santa-Marina; Eva Reischl; Christine Frithioff-Bøjsøe; David Meyre; Eleanor Wheeler; Ken Ong; Ellen A Nohr; Tanja G M Vrijkotte; Gerard H Koppelman; Robert Plomin; Pål R Njølstad; George D Dedoussis; Philippe Froguel; Thorkild I A Sørensen; Bo Jacobsson; Rachel M Freathy; Babette S Zemel; Olli Raitakari; Martine Vrijheid; Bjarke Feenstra; Leo-Pekka Lyytikäinen; Harold Snieder; Holger Kirsten; Patrick G Holt; Joachim Heinrich; Elisabeth Widén; Jordi Sunyer; Dorret I Boomsma; Marjo-Riitta Järvelin; Antje Körner; George Davey Smith; Jens-Christian Holm; Mustafa Atalay; Clare Murray; Hans Bisgaard; Mark I McCarthy; Early Growth Genetics Consortium; Vincent W V Jaddoe; Struan F A Grant; Janine F Felix
Source
PLoS Genetics, Vol 16, Iss 10, p e1008718 (2020)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values