학술논문
Glioblastoma: Relationship between Metabolism and Immunosuppressive Microenvironment
Document Type
article
Source
Cells, Vol 10, Iss 12, p 3529 (2021)
Subject
Language
English
ISSN
2073-4409
Abstract
Glioblastoma (GBM) is the most aggressive brain tumor in adults and is characterized by an immunosuppressive microenvironment. Different factors shaping this tumor microenvironment (TME) regulate tumor initiation, progression, and treatment response. Genetic alterations and metabolism pathways are two main elements that influence tumor immune cells and TME. In this manuscript, we review how both factors can contribute to an immunosuppressive state and overview the strategies being tested.