학술논문
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
Document Type
article
Author
Eva G. Álvarez; Jonas Demeulemeester; Paula Otero; Clemency Jolly; Daniel García-Souto; Ana Pequeño-Valtierra; Jorge Zamora; Marta Tojo; Javier Temes; Adrian Baez-Ortega; Bernardo Rodriguez-Martin; Ana Oitaben; Alicia L. Bruzos; Mónica Martínez-Fernández; Kerstin Haase; Sonia Zumalave; Rosanna Abal; Jorge Rodríguez-Castro; Aitor Rodriguez-Casanova; Angel Diaz-Lagares; Yilong Li; Keiran M. Raine; Adam P. Butler; Iago Otero; Atsushi Ono; Hiroshi Aikata; Kazuaki Chayama; Masaki Ueno; Shinya Hayami; Hiroki Yamaue; Kazuhiro Maejima; Miguel G. Blanco; Xavier Forns; Carmen Rivas; Juan Ruiz-Bañobre; Sofía Pérez-del-Pulgar; Raúl Torres-Ruiz; Sandra Rodriguez-Perales; Urtzi Garaigorta; Peter J. Campbell; Hidewaki Nakagawa; Peter Van Loo; Jose M. C. Tubio
Source
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Subject
Language
English
ISSN
2041-1723
Abstract
Hepatitis B virus (HBV) infection and DNA integration is a frequent cause of hepatocellular carcinoma (HCC), but the consequences of this process are not fully understood. Here the authors use whole-genome and long-read sequencing data from HCC patient samples to study the timing and alterations induced by HBV insertions.